Thomas K. Lee, M.D., Ph.D.

 

Titles

President, NewPath Labs
Medical Director, NewPath Labs

Subspecialties

Urologic Pathology
Anatomic Pathology
Surgical Pathology

Education

Medical School: George Washington University
Ph.D., University of Rochester, Toxicology

Residency/Internship

Residency: The Johns Hopkins Hospital (Anatomic/Urologic Pathology)

Fellowships

Surgical Pathology: Stanford University Medical Center

Board Certified in

Anatomic Pathology

Publications

• Lee TK and Ro JY. (2018). Spectrum of cribriform proliferations of the prostate: from benign to malignant. Arch Pathol Lab Med 142(8):938-946
• Fajardo DA, Miyamoto H, Miller JS, Lee TK, Epstein JI. (2011) Identification of Gleason pattern 5 on prostatic needle core biopsy: frequency of underdiagnosis and relation to morphology. Am J Surg Pathol. 35(11):1706-11
• Chaux A, Karram S, Miller JS, Fajardo DA, Lee TK, Miyamoto H, Netto GJ. (2012) High-grade papillary urothelial carcinoma of the urinary tract: a clinicopathologic analysis of a post-World Health Organization/International Society of Urological Pathology classification cohort from a single academic center. Human Pathol. 43(1):115-20.
• Lee TK, Chaux, A, Karram S, Miyamoto H, Miller JS, Fajardo DA, Epstein JI, and Netto GJ. (2011) Papillary Urothelial Neoplasm of Low Malignant Potential of the Urinary Bladder: Clinicopathologic and Outcome Analysis from a Single Academic Center. Human Pathol. 42(11):1799-803.
•  Ling SZ , Chang XF , Lee TK, Marchionni L, Netto GJ, Sidransky D, Schultz L, Chaux A, and Berman, DM. (2011) An EGFR-ERK1/2-Sox9 Signaling Cascade Links Urothelial Development, Regeneration, and Cancer. Cancer Res. 71(11):3812-21.
• Miyamoto H, Brimo F, Schultz L, Ye H, Miller JS, Fajardo DA, Lee TK, Epstein JI, Netto GJ. (2010) Low-grade papillary urothelial carcinoma of the urinary bladder: a clinicopathologic analysis of a post-World Health Organization/International Society of Urological Pathology classification cohort from a single academic center. Arch Pathol Lab Med.134(8):1160-3.
• Lee TK, Miller JS, Epstein JI. (2010) Rare histological patterns of prostatic ductal adenocarcinoma. Pathology. 42(4):319-24.
• Lee TK, Miyamoto H, Osunkoya, AO, Guo CC, Weiss SW, and Epstein JI. (2010) Smooth muscle neoplasms of the urinary bladder: A clinicopathological study of 51 cases. Am. J. Surg. Pathol. 34(4):502-9.
• Lee TK, Hammond CL, and Ballatori N. (2001) Intracellular glutathione regulates taurocholate transport in HepG2 cells. Toxicol. Appl. Pharmacol. 174(3):207-15.
• Shim V, Baker RJ, Jing W, Puentes R, Agersborg SS, Lee TK, Goreal W, Achacoso N, Lee C, Villasenor M, Lin A, Kapali M, Habel LA. (2023) Evaluation of the international Ki67 working group cut point recommendations for early breast cancer: comparison with 21-gene assay results in a large integrated health care system. Breast Cancer Research and Treatment. https://doi.org/10.1007/s10549-023-07118-4.
• Owyong M, Lotan Y, Kapur, P, Panwar V, McKenzie T, Lee TK, Zi X, Martin JW, Mosbah A, Abol-Enein H, Ghoneim M, and Youssef RF (2019) Expression and prognostic utility of PD-L1 in patients with squamous cell carcinoma of the bladder. Urol Oncol. Jul;37(7):478-484.
• Okhunov Z, Mao R, Jefferson FA, Yoon R, Patel RM, Lee TK, Huang J, Zhang Y, Ghoniem GG, Li GP, Landman J. (2019) Initial Evaluation of a Novel Modulated Radiofrequency-based Bladder Denervation Device. Urology. 2019 Dec;134:237-242.
• Kaler KS, Cooper V, O’Leary M, Valley ZA, Lee TK, Patel RM, Landman J, and Clayman RV. (2019) Laser Endoscopic X-Ray-Guided Intrarenal Tract: Comparison Among Renal Access Modalities in the Porcine Kidney. J Endourol. 2019 Jul 16. [Epub ahead of print]
• Daun M, Fardin S, Ushinsky A, Batra S, Nguyentat M, Lee T, Uchio E, Lall C, and Houshyar R. PI-RADS Version 2 Is an Excellent Screening Tool for Clinically Significant Prostate Cancer as Designated by the Validated International Society of Urological Pathology Criteria: A Retrospective Analysis. Curr Probl Diagn Radiol. 2019 Jun 29.[Epub ahead of print]
• Farzaneh T, Wang B, Clark N, Eade-Viele C, Kelner J, Rodgers J, Sempa G, Detweiler N, Kasmarek T, Lee T, Zhao X, Monuki ES, and Rezk SA. (2019) Crucial role for pathology residents in laboratory self-inspection, a single Institute’s experience. Pract Lab Med. 2019 May 17;16:e00123. doi: 10.1016/j.plabm.2019.e00123.
• Klempner SJ, Gowen K, Lee TK, Zhu VW, Schrock AB, Miller VA, Ali SM, and Ou SI. (2018) Carving out another slice of the pie: Exceptional response to single agent imatinib in an asian female never-smoker with advanced NSCLC with a de-novo PDGFR-α N848 K mutation. Lung Cancer 124:86-89.
• Nguyen TB, Ushinsky A, Yang A, Nguyentat M, Fardin S, Uchio E, Lall C, Lee T, Houshyar R. (2018) Utility of quantitative apparent diffusion coefficient measurements and normalized apparent diffusion coefficient ratios in the diagnosis of clinically significant peripheral zone prostate cancer. Br J Radiol. 91(1088):20180091.
• Nguyen N, Nakasaki M, Lee T, Lu D. (2018) Cytological diagnosis of paraganglioma as a pancreatic mass: a case report. Diagn Cytopathol. (Jun 7. doi: 10.1002/dc.23974).
• Lyou Y, Barber E, Mehta R, Lee T, Goreal W, Parajuli R. (2018) Radiation Associated Angiosarcoma (RAS) of the Breast: A Case Report and Literature Review. Case Rep Oncol. 11:216–220.
• Lama DJ, Safiullah S, Patel RM, Lee TK, Balani JP, Zhang L, Okhunov Z, Margulis V, Savage SJ, Uchio E, Landman J. (2018) Multi-Institutional Evaluation of Upper Urinary Tract Biopsy Using Backloaded Cup Biopsy Forceps, a Nitinol Basket, and Standard Cup Biopsy Forceps. Urology 117:89-94.
• Okhunov Z, Yoon R, Spradling K, Suarez M, Lusch A, Hwang C, Osann K, Lee TK, Landman J. (2018) Evaluation and Comparison of Contemporary Energy-based Surgical Vessel Sealing Devices. J Endourol 32(4):329-337.
• Joshu CE, Peskoe SB, Heaphy CM, Kenfield SA, Mucci LA, Giovannucci EL, Stampfer MJ, Yoon GS, Lee TK, Hicks JL, DeMarzo AM, Meeker AK, Platz EA. (2018) Current or recent smoking is associated with more variable telomere length in prostate stromal cells and prostate cancer cells. The Prostate 78(3):233-238.
• Lall C, Bura V, Lee TK, Bhosale P, Faria SC, Choi JI, Wang ZJ. (2018) Diffusion-weighted imaging in hemorrhagic abdominal and pelvic lesions: restricted diffusion can mimic malignancy. Abdom Radiol (NY) 43(7):1772-1784.
• Nguyentat M, Ushinsky A, Miranda-Aguirre A, Uchio E, Lall C, Shirkhoda L, Lee T, Green C, Houshyar R. (2017) Validation of Prostate Imaging-Reporting and Data System Version 2: A Retrospective Analysis. Curr Probl Diagn Radiol. 2017 Oct 12. S0363-0188(17)30188-3.
• Sung CT, Shetty A, Menias CO, Houshyar R, Chatterjee S, Lee TK, Tung P, Helmy M, Lall C. (2017) Collision and Composite Tumors; Radiologic and Pathologic Correlation. Abdominal Radiology 42(12):2909-2926.
• Ou SI, Lee TK, Young L, Fernandez-Rocha MY, Pavlick D, Schrock AB, Zhu VW, Milliken J, Ali SM, Gitlitz B. (2017) Dual occurrence of ALK G1202R solvent front mutation and small cell lung cancer transformation as resistance mechanisms to second generation ALK inhibitors without prior exposure to crizotinib. Pitfall of solely relying on liquid re-biopsy? Lung Cancer 106:110-114.
• Darvishazadeh, A, McEachern, W, Lee, TK, Bhosale, P, Shirkhoda, A, Menias, C, and Lall, C. (2016) Deep Pelvic Endometriosis: A Radiologist’s Guide to Key Imaging Features with Clinical and Histopathologic Review. Abdominal Radiology, 41(12):2380-2400.
• Weinberg BA, Gowen K, Lee TK, Ou SI, Bristow R, Krill L, Almira-Suarez MI, Ali SM, Miller VA, Liu AV, Klempner AJ. (2016) Comprehensive genomic profiling aids in distinguishing metastatic recurrence from second primary cancers. Oncologist, 22(2):152-157.
• Vernez SL, Okhunov Z, Khoyilar C, Wikenheiser J, Khoyilar C, Dutta R, Osann K, Kaler K, Lee TK, Clayman RV, and Landman J. (2016) Precise characterization and three-dimensional reconstruction of the autonomic nerve distribution of the human ureter. J Urol., 197(3 pt.1): 723- 729.
• Wood M, Lee TK, Armstrong WB, and Wang BY. (2016) Cervical Spine Synovial Chondromatosis: A Case Report and Literature Review. Med Reports & Case Studies, 1(2):114.
• Klempner SJ, Gershenhorn B, Tran P, Lee TK, Erlander MG, Gowen K, Schrock AB, Ross JS, Miller VA, Stephens PJ, Ou SI, Ali SM. (2016) BRAFV600E Mutations in high grade colorectal neuroendocrine tumors may predict responsiveness to BRAF-MEK combination therapy. Cancer Discoveries, 6(6):594-600.
• Joshu CE, Peskoe SB, Heaphy CM, Kenfield SA, Van Blarigan E, Mucci LA, Giovannucci E, Stampfer MJ, GhilSuk Yun, Lee TK, Hicks JL, De Marzo AM, Meeker AK, Platz EA. (2015) Pre-diagnostic obesity and physical inactivity are associated with shorter telomere length in prostate stromal cells. Cancer Prev Res (Phila). 8(8):737-42.
• Heaphy CM, Yun GS, Peskoe SB, Joshu CE, Lee TK, Giovannucci E, Mucci LA, Kenfield SA, Stamfer MJ, Hicks JL, Demarzo AM, Platz EA, Meeker AK. (2013) Prostate Cancer Cell Telomere Length Variation and
• Stromal Cell Telomere Length as Prognostic Markers for Metastasis and Death. Cancer Discov. 3(10):1130-41.
• Hammond CL, Lee TK, and Ballatori N. (2001) Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes. J. Hepatol. 34(6):946-54.
• Li L, Lee TK, Meier PJ, and Ballatori N. (1998) Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter. J. Biol. Chem. 273(26).
• Li L, Lee TK, and Ballatori N. (1997) Functional re-evaluation of the putative glutathione transporters, RcGshT and RsGshT. Yale J. Biol. Med. 70(4):301-10.
• Lee TK, Li L, and Ballatori N. (1997) Hepatic glutathione and glutathione S-conjugate transport mechanisms. Yale J. Biol. Med. 70(4):287-300.